Figure 4: Differences between MAIT TCR–MR1–6-FP and MAIT TCR–MR1–RL-6-Me-7-OH complexes. | Nature Communications

Figure 4: Differences between MAIT TCR–MR1–6-FP and MAIT TCR–MR1–RL-6-Me-7-OH complexes.

From: Recognition of vitamin B metabolites by mucosal-associated invariant T cells

Figure 4

(a) Water-mediated interaction between CDR3α of MAIT TCR and 6-FP. (b) Overlay of MAIT TCR–MR1–6-FP and MAIT TCR–MR1–RL-6-Me-7-OH complexes. Arrow indicates 75° rotation of RL-6-Me-7-OH compared with 6-FP. (c) H-bond interaction between CDR3α of MAIT TCR and RL-6-Me-7-OH. MR1, grey; CDR3α, yellow; 6-FP, green; RL-6-Me-7-OH, magenta; blue circle, water molecule; H-bond interactions are shown in black dashed lines.

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