Figure 2: Reduction of COX activity in muscles and compromised exercise performance in Cox7rp KO mice. | Nature Communications

Figure 2: Reduction of COX activity in muscles and compromised exercise performance in Cox7rp KO mice.

From: A stabilizing factor for mitochondrial respiratory supercomplex assembly regulates energy metabolism in muscle

Figure 2

(a) Reduced COX activity in Cox7rpKO mice. COX staining of the quadriceps femoris of 4-month-old WT, Cox7rpKO (KO), COX7RP-Tg (Tg) and COX7RP-Tg:Cox7rpKO (TgKO) mice. Scale bar, 100 μm. (b) Compromised exercise performance in Cox7rpKO mice. Four-month-old KO, Tg and TgKO mice, as well as WT controls were subjected to a forced treadmill exercise test. Data are presented as means±s.d. (n=7 or 8). *P<0.05, **P<0.01; Dunnett’s post hoc test. (c) Increase in the respiration quotient in Cox7rpKO mice. CO2 production, O2 consumption and RQ were analysed during the above treadmill exercise test. Data are presented as means±s.d. (n=7 or 8). *P<0.05, **P<0.01; Dunnett’s post hoc test.

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