Figure 2: Supervised analysis reveals a hypermethylation phenotype associated with IDH mutation.
From: Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2
(a) Hierarchical clustering of the top 3,057 hyper and hypo-MVPs (Wilcoxon rank-sum test P≤0.001 and |Δß|≥0.35) between IDH mt and wt. The samples cluster into three groups: low/unmethylated wt cluster (1) intermediate/high methylation mt cluster (2) highly methylated mt cluster (3) 2-HG levels positively correlate with IDH mutation and hypermethylation. (b) Frequency distribution of median ß-value differences between mt and wt sample groups in selected (top 3,057) probes. 99.5% (3,042 of 3,057) are hypermethylated in mt samples relative to wt.
