Figure 3: IDH mt-associated MVPs are enriched in CpG islands and gene promoters. | Nature Communications

Figure 3: IDH mt-associated MVPs are enriched in CpG islands and gene promoters.

From: Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2

Figure 3

(a) Percentage enrichment of epigenomic features (random resampling P-value≤0.001) as annotated on the Infinium 450 K BeadChip array: CpG Islands are defined as DNA sequences with GC content ≥50% and a CpG observed/expected ratio ≥0.6; CpG Shores correspond to the 2 kb sequences directly upstream and downstream of a CpG Island. Enrichment was assessed by repeated random sampling. Islands and shores are enriched for by 19.1 and 11.3%, respectively. (b) Percentage enrichment of genomic features (P-value≤0.001). TSS1500=1,500 bp upstream of transcription start site; TSS200=200 bp upstream of transcription start site; the TSS1500 region is enriched for by 9%, while probes located within the gene body are depleted by 6.4%.

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