Figure 5: Protein–protein interaction network.
From: Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer
Network is built with quantitative proteomics data from (a) DNA-binding and (b) cytosolic fraction and indicates an altered protein–protein interaction environment for RARA and ER in tamoxifen resistance. Previously reported protein–protein interactions for ER or RARA were compiled from APID, PINA and ingenuity answers databases and overlaid with quantitative proteomics data from this study. Proteins with at least one significant protein ratio between samples (P-value <0.01, t-test) are displayed.
