Figure 3: Quantification of TERT mRNA expression level in thyroid tumours. | Nature Communications

Figure 3: Quantification of TERT mRNA expression level in thyroid tumours.

From: Frequency of TERT promoter mutations in human cancers

Figure 3

We have performed qPCR in normal thyroid tissue (N), a pool of mRNA of nine normal thyroids (pool N) and thyroid tumours with different genetic backgrounds: without known genetic alterations (wt), with BRAF mutation (B), with RET rearrangement (RET), with RAS mutation (R), with TERT mutation (T), with TERT and BRAF mutations (BT) or with RAS and TERT mutations (RT). (a) Each bar represents TERT mRNA expression in an individual tumour measured in triplicate. TERT mRNA levels were normalized against TBP mRNA levels. (b) Quantification of TERT mRNA mean expression level in thyroid tumours with and without TERT mutation. Error bars represent s.e.m. The difference is statistically significant (P<0.0001, unpaired t-test).

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