Figure 6: PDK1 regulates carbon entry into the TCA cycle in hypoxia.
From: Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells
(a) Reductive glutamine contribution to citrate for different stress conditions with and without the PDK inhibitor DCA. (b) NAD+/NADH ratio for different stress conditions. Ctrl denotes standard culture condition. All error bars indicate the s.d. All P-values (Student’s t-test, two-tailed, unequal variance) and error bars are calculated from three independent replicates.
