Figure 4: Protein abundance has an influence on the timing of pathway activation in vivo.
From: Dynamic optimization identifies optimal programmes for pathway regulation in prokaryotes
We determined the average positional coexpression bias for each organism of the MicroCyc collection31 for low and high abundance enzymes, given the actual operon structure (orange values) and a randomized operon structure (blue values). Each point corresponds to the average positional coexpression bias of an organism. Lines indicate the distribution of these values. Black bars denote the median of each distribution. Only data for organisms that had at least one low abundance enzyme or high abundance enzyme coexpressed with at least one other enzyme in an operon in the pathway shown (293 and 327 organisms, respectively).
