Figure 1: Neural consequences of sleep deprivation on food desirability.
From: The impact of sleep deprivation on food desire in the human brain
Sleep deprivation triggered marked decreases in the anterior cingulate, left lateral orbital frontal cortex and anterior insular reactivity to food desirability (a). In addition, sleep deprivation resulted in a significant increase in amygdala reactivity to food desirability but no significant difference in ventral striatum reactivity (b). All parameter estimates are from a GLM with a parametric contrast of individual ‘want’ ratings from 23 participants. Whole-brain analysis (above) are thresholded at P<0.005 for display purposes. ROI analysis (represented by the bar graphs) are mean parameter estimates with s.e.m. extracted from 5-mm spheres centred at foci taken from previous literature (see Methods; circles indicate general areas of interest not specific foci; *P<0.05 for paired t-tests across 23 participants and **P<0.05 with Bonferroni correction for five ROIs). Table 2 reports whole-brain activation differences between sleep-rested and deprived conditions beyond our a priori ROIs (P<0.001 uncorrected using voxel-wise paired t-tests). Error bars are represented as s.e.m.
