Figure 3: TRB gene usage for genotype analysis. | Nature Communications

Figure 3: TRB gene usage for genotype analysis.

From: IMGT/HighV QUEST paradigm for T cell receptor IMGT clonotype diversity and next generation repertoire immunoprofiling

Figure 3

Histograms for the TRBV genes (a), TRBD genes (b) and TRBJ genes (c) display results from the ‘1 copy’ ‘single allele’ (for V and J) (58,958 sequences, average sequence length of 440 nt, average V-D-J-REGION length of 335 nt), which are the result output from the IMGT/HighV-QUEST detailed statistical analysis performed on ‘MIDA+MIDB’. The histograms show the genes, per group, from 5′ to 3′ in the TRB locus1, with the number of sequences shown in parentheses. The TRBV30 gene is located downstream of the TRBC2 gene in the opposite orientation of transcription1. TRBD1 is upstream of TRBJ1-1 and TRBD2 upstream of TRBJ2-1 (ref. 1). The histograms of the TRBD and TRBJ genes are displayed separately, owing to the differences of scale (sequences being assigned to 2 and 13 genes, respectively). These histograms and corresponding tables online allow a genotype and haplotype identification if the sequences are obtained from a single individual, as in this study. They include rearranged sequences with in-frame and out-of-frame junctions.

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