Figure 3: Effects on the sympathetic baroreflex and vascular infiltration.
From: The carotid body as a putative therapeutic target for the treatment of neurogenic hypertension
(a) The renal sympathetic activity baroreflex function curve is rightwards shifted over lower pressure ranges after carotid sinus nerve denervation (CSD) in SH rats (n=6) but no changes were observed in Wistar rats (n=6, Supplementary Fig. S3). Percent total leukocytes (CD45+ cells) in the aorta of surgical sham (SS), RD and CSD animals (b). There was reduced vascular T-cell infiltration following RD and CSD in the SH rats as the percentage of T lymphocytes (CD45+CD3+ cells) in the aorta of RD and CSD animals was less relative to SS (n=6 and 7 per group; c). Representative flow cytometry contour plot showing T lymphocytes (CD45+CD3+) in aortic samples of each rat group (d). All data are shown as mean±s.e.m. *P<0.05, analysis of variance.
