Figure 4: Immediate effects of carotid sinus denervation.
From: The carotid body as a putative therapeutic target for the treatment of neurogenic hypertension
The time course of the fall in sympathetic nerve activity (raw and integrated) after carotid sinus nerve denervation (CSD) was compared for the internal cervical (iCSN) and lumbar (lSN) sympathetic post-ganglionic nerves in situ. By 40 min, there was a significant decrease in the sympathetic nerve activity in both outflows (a). Note the decrease in the amplitude of respiratory-modulated discharge (P<0.05; b). The peak response was achieved at 60 min post CSD as activity levels at 75 or 90 min were not different from the level recorded at 40 min post CSD but were different from their own baseline (c). Data are shown as mean±s.e.m. *P<0.05, **P<0.01, ***P<0.001, repeated-measures analysis of variance; n≥5. PN, phrenic nerve; PP, perfusion pressure (aortic); Pre-I, pre-inspiratory; TH, Traube–Hering arterial pressure waves.
