Figure 1: Overview of the PGSR approach.
From: Genome signature-based dissection of human gut metagenomes to extract subliminal viral sequences
TUPs of all large fragments (10 kb or over) from 139 human gut metagenomes were calculated, and compared with those of phage genome sequences used as drivers. All metagenomic fragments producing tetranucleotide correlation values of 0.6 or over to any driver sequence were retained, and subjected to functional profiling to resolve phage and non-phage sequences captured. See Table 1 and Supplementary Figs S1–S3 for details of driver sequences. See Supplementary Table S1 for details of human gut metagenomes utilized. *Tetranucleotide usage patterns and correlations were calculated using TETRA 1.0 (ref. 46).
