Figure 2: Effect of glucose consumption on liver histology and function. | Nature Communications

Figure 2: Effect of glucose consumption on liver histology and function.

From: Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome

Figure 2

WT mice and KHK-A/C KO mice were given 10% glucose water, or tap water for 14 weeks with normal chow diet ad libitum (n=6 per group). (a) Liver weight. (b) Gross images of liver showing increased liver size and pale colour in WT but not in KHK-A/C KO mice given glucose (size bar: 1 cm). (c) Representative images of oil red O staining, demonstrating increased fat accumulation (red) in WT but not in KHK-A/C KO mice given glucose (size bar 50 μM). (d) Representative images of H&E staining showing areas of macrosteatosis (white vesicles) in zone 2 and microsteatosis in zone 1 (surrounding the central vein, CV) in WT but not in KHK-A/C KO mice given glucose. PT, portal triad. (e) Intrahepatic triglyceride levels (size bar 50 μM). (f) Intrahepatic cholesterol levels. (g) Serum AST levels. (h) Serum ALT levels. Data represent means±s.e.m. *P<0.05, **P<0.01, ***P<0.001 versus respective water control. #P<0.05. ##P<0.01. ###P<0.001 (analysis of variance, Tukey’s post hoc test).

Back to article page