Figure 5: MRs of FGFR2 signalling.
From: Master regulators of FGFR2 signalling and breast cancer risk
(a) Number of regulons enriched for FGFR2 signatures (Exp1–3) in breast cancer cohort I and cohort II and their overlap. The percentage of the overlap is given relative to the total number in cohorts I and II. There is substantial overlap between the MRs derived for different FGFR2 signatures, and the consensus corresponds to the five MRs shown in b. (b) The MRs enriched for FGFR2 signatures in breast cancer in both cohorts. Enrichment was calculated using the three expression signatures (Exp1–3) on networks derived from breast cancer cohort I and II, normal breast or T-ALL, that were filtered by DPI using either a 0 (black circle) or 0.05 threshold (grey circles). (c) Breast cancer filtered TN enriched for the FGFR2-responsive genes. The network shows the five MRs, each one comprising one TF (square nodes) and all inferred targets (round nodes) applying a DPI threshold of 0.01.
