Figure 7: Overlap between regulons in the unfiltered TN.
From: Master regulators of FGFR2 signalling and breast cancer risk
(a) The heatmap shows the hierarchical clustering on the Jaccard similarity coefficient (in shades of blue) computed among all regulons in the unfiltered TN derived from cohort I. Sidebars show the enrichment P-values (shades of orange) from the MRA analysis for FGFR2-associated gene expression signatures (Exp1–3) at the top of the graph and the MRA analysis for E2-associated gene expression signatures (E2 Ctrl 1–3) derived for each experiment on the left. (b) Hierarchical clustering on the Jaccard similarity coefficient focused on the overlap between the five MRs of the FGFR2 response. (c) The unfiltered TN in breast cancer, with edges depicting the overlap of regulons. The network is calculated on cohort I and different intensities of orange indicate enrichment of a regulon in 1, 2 or 3 of the FGFR2 gene signatures. Arrows highlight the ESR1 and PTTG1 regulons. Unconnected regulons and connections corresponding to JC <0.4 are not shown (a full network is shown in Supplementary Fig. S13).
