Figure 8: Enrichment of the breast cancer AVS in FGFR2 master regulators following cis-eQTL validation.
From: Master regulators of FGFR2 signalling and breast cancer risk
(a) VSE plots and cis-eQTL for all genes in the regulons. (b) VSE plots and cis-eQTL for genes that respond to FGFR2 perturbation. (c) VSE plots and cis-eQTL for genes that do not respond to FGFR2 perturbation. (d–e) VSE plots and cis-eQTL for genes that respond to FGFR2 perturbation using regulons either derived from ER+ (d) or ER− (e) samples. Box plots show the normalized null distributions (box: 1st–3rd quartiles; bars: extremes). Black diamonds show the corresponding VSE scores. Red diamonds highlight mapping tallies that satisfy a Bonferroni-corrected threshold for significance (P<1e–4). P-values are based on null distributions from 1,000 MRVSs.
