Figure 9: Rescue of puberty onset and fecundity in Gpr54>−/−-Tg rescue mice.
From: Dependence of fertility on kisspeptin–Gpr54 signaling at the GnRH neuron
Mean+s.e.m. values showing (a) the day of vaginal opening in three genotypes (n=6 each). (b) Estrous cycle length in three genotypes (n=6 each); wild-type and Gpr54−/−;Tg rescue are not significantly different. (c) Fecundity over 120 days for three representative individual female mice (each line) from each genotype with symbols showing the times at which each litter was born. Gpr54−/− mice failed to generate any litters. (d) Onset of reproductive competence for male mice of three genotypes (n=6 each). Gpr54−/− mice failed to sire any litters. (e) Pups per litter were not different between wild-type and Gpr54−/−;Tg rescue male mice. (f) Fecundity over 120 days for three representative individual male mice (each line) from each genotype.
