Figure 1: Loss of gluconeogenesis in murine hepatocarcinoma.
From: Switch of glycolysis to gluconeogenesis by dexamethasone for treatment of hepatocarcinoma
Normal BALB/c mice and H22 hepatocarcinoma-bearing mice were fed or subjected to 24 h fasting. The expression of PEPCK and G6Pase in normal liver and hepatocarcinoma tissues was analysed by reverse transcriptase–PCR (a, left), real-time PCR (a, right), western blot (b) and immunohistochemical staining. (c) Hepatocarcinoma and liver tissues were used to analyse the levels of lactate, scale bar, 20 μm (d). Data shown are representative of three independent experiments and error bars represent means±s.e.m., **P<0.01 (analysis of variance).
