Figure 2: CTNNA2 and CTNNA3 mutations identified in laryngeal carcinomas. | Nature Communications

Figure 2: CTNNA2 and CTNNA3 mutations identified in laryngeal carcinomas.

From: Cell–cell adhesion genes CTNNA2 and CTNNA3 are tumour suppressors frequently mutated in laryngeal carcinomas

Figure 2

(a) Schematic representation of the human CTNNA2 and CTNNA3 adhesion proteins with different somatic alterations found in larynx cancer samples (black) and COSMIC (grey). Green blocks identify the two vinculin-like domains in each α-catenin. CTNNA2 and CTNNA3 are depicted bound to cadherin (violet rectangles) through β-catenin (red arcs), and to actin filaments (grey circles). (b) Structural localization of CTNNA2 and CTNNA3 mutations. The residues corresponding to mutations in CTNNA2 (red) and CTNNA3 (orange) are shown over the structure of a CTNNA1 dimer (pdb id. 4IGG).

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