Figure 6: β-catenin activity in SCC-2 cells with loss- or gain-of-function of CTNNA2 and CTNNA3. | Nature Communications

Figure 6: β-catenin activity in SCC-2 cells with loss- or gain-of-function of CTNNA2 and CTNNA3.

From: Cell–cell adhesion genes CTNNA2 and CTNNA3 are tumour suppressors frequently mutated in laryngeal carcinomas

Figure 6

β-catenin transcriptional activity in SCC-2 cells after silencing (i) or overexpression (o) of CTNNA2 (a) and CTNNA3 (b). TOP, reporter with optimal Tcf-binding site; FOP, background assessed with Far-from-optimal Tcf-binding site. Statistical analyses were performed by Student’s t-test with *P<0.05 and ***P<0.005. Error bars represent mean±s.e.m. of three biological replicates.

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