Figure 2: Activation of proteins nominated by the S score was confirmed by an orthogonal and low-throughput method. | Nature Communications

Figure 2: Activation of proteins nominated by the S score was confirmed by an orthogonal and low-throughput method.

From: Reconstructing targetable pathways in lung cancer by integrating diverse omics data

Figure 2

The western blot demonstrates high levels of total and phosphorylated protein for MET, LCK, PAK1 and β-catenin in KRAS-Dep cells. This pattern confirms the utility of our integrative analysis in nominating differentially activate proteins. It also suggests signalling modules that are differentially active in KRAS-Dep but not in KRAS-Ind cell lines. Total RAS and β-actin were used as controls.

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