Figure 2: MPH self-administration increases the potency of releasers. | Nature Communications

Figure 2: MPH self-administration increases the potency of releasers.

From: Methylphenidate amplifies the potency and reinforcing effects of amphetamines by increasing dopamine transporter expression

Figure 2

(a,b) Representative traces showing cocaine- and nomifensine-induced uptake inhibition at the DAT, respectively. Colour plots show the concentration of dopamine (green) over time. The ability of the blockers, (c), cocaine (n=5 control, 6 MPH self-administration), and (d), nomifensine (n=5 per group), to inhibit the DAT following MPH self-administration was unchanged. (e,f) Representative traces showing AMPH- and METH-induced uptake inhibition, respectively. Colour plots show the concentration of dopamine (green) over time. The ability of the releasers (g) AMPH (*P<0.05 versus control, n=5 per group, two-way ANOVA) and, (h), METH (**P<0.01, ***P<0.001 versus control, n=7 control, 5 MPH self-administration, two-way ANOVA) to inhibit the DAT following MPH self-administration was enhanced. Error bars are reported as mean±s.e.m. CTRL, control; DA, dopamine; SA, self-administration; METH, methamphetamine; COC, cocaine; MPH, methylphenidate; AMPH, amphetamine; DAT, dopamine transporter.

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