Figure 2: Architecture of the SAMHD1 tetramer. | Nature Communications

Figure 2: Architecture of the SAMHD1 tetramer.

From: Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase

Figure 2

(a) A ribbon representation. A substrate (red) and Zn2+ (grey) at the active site, two dGTP activators (yellow and pink) and Mg2+ (green) at the allosteric site are shown as spheres. The interface between chains A and C is not seen in 3U1N. Chains A and B also exist in 3U1N as a dimer. (b) Rotated around the vertical axis by 90°. The novel symmetric interface between chains A and C is separated by a line.

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