Figure 3: Features of a single chain in the SAMHD1 tetramer. | Nature Communications

Figure 3: Features of a single chain in the SAMHD1 tetramer.

From: Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase

Figure 3

(a) A representation of the SAMHD1 monomer with the major lobe, minor lobe and C-terminal region. The first two β-strands in SAMHD1c′ tetramer structure are indicated by a blue arrow. The CDK1 phosphorylation site T592 and the surrounding amino acids are indicated by a red arrow. (b) A surface representation in the same position as in a. The regions at the surface of chain A that are buried by chains B, C and D (shown in blue, purple and orange, respectively). The blue, purple and orange interface areas are ~1,800, 2,100 and 600 Å2, respectively, as calculated by the PDBePISA website.

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