Figure 4: Detailed views of the interactions in the allosteric site. | Nature Communications

Figure 4: Detailed views of the interactions in the allosteric site.

From: Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase

Figure 4

(a) Both dGTP molecules are buried in the allosteric site cavity formed by three chains (green, pink and blue). Contributions from all three chains are critical for dGTP binding and allosteric site stability. Interactions contributed by the chains in green and pink are shown. K116 and N119 (from the green chain) located in the first β-sheet (β1) form H bonds with the dGTP molecule. (b) Interactions contributed by the blue chain are shown.

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