Figure 5: A detailed view of the interaction between chains A and C, and substrate interaction in the active site. | Nature Communications

Figure 5: A detailed view of the interaction between chains A and C, and substrate interaction in the active site.

From: Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase

Figure 5

(a) The symmetric interface between two molecules around the axis (shown in the middle as a line). Helix A351–V378 (shown in blue and purple from different chains) has a key role in this interaction. (b) A close-up view of the active site. The substrate is shown in the ball-and-stick model. The residues shown as blue sticks interact directly with dGTP, and all of them are from one chain.

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