Figure 7: A model of Pan-cancer suppressor pathway regulation by miR-17-19-130 superfamily as defined by AGO-CLIP analysis.
From: Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif
The microRNA-17-19-130 superfamily heavily targets critical TS in multiple pathways, including the TGFβ pathway, the phosphoinositide 3-kinase/AKT pathway and the P53 pathway. Additional target site mutation analysis reveals ablation of a miR-17-mediated negative feedback loop through mutation of the miR-17 binding site on the SKIL OC 3′-UTR, demonstrating a novel mechanism of tumour escape from microRNA regulation.
