Table 1 Summary of logistic regression results for rs11098403 across cohorts.

From: Genome-wide association study implicates NDST3 in schizophrenia and bipolar disorder

Sample

Ethnicity

Case diagnosis

Total samples

Controls

Cases

MAF controls

MAF cases

Odds ratio

Additive P -value

Reference (see supplement)

Discovery

 Ashkenazi*

Caucasian

Schizophrenia

2,544

1,640

904

0.38

0.47

1.41

6.55E−09

 

Replication/extension

 MGS EA

Caucasian

Schizophrenia

4,942

2,056

2,886

0.27

0.28

1.05

0.127

49

 ZHH

Caucasian

Schizophrenia

317

140

177

0.29

0.32

1.15

0.208

50

 MGS AA*

African–American

Schizophrenia

1,875

954

921

0.25

0.27

1.09

0.12

49

 Japan*

Asian

Schizophrenia

1,080

530

550

0.16

0.17

1.06

0.238

51

 Munich

Caucasian

Schizophrenia

842

412

430

NA

NA

1.1

0.287

52

 Aberdeen

Caucasian

Schizophrenia

892

441

451

NA

NA

1.21

0.03

52

 GAIN

Caucasian

Bipolar

1,710

689

1,021

0.25

0.28

1.13

0.058

53

 German

Caucasian

Bipolar

1,982

1,300

682

0.29

0.31

1.05

0.255

54

 WTCCC

Caucasian

Bipolar

4,806

2,938

1,868

0.25

0.27

1.1

0.019

55

 Taiwan*

Asian

Bipolar

2,000

1,000

1,000

0.15

0.16

1.06

0.25

56

 Ashkenazi*

Caucasian

Bipolar

2,745

2,531

214

0.38

0.43

1.24

0.0177

 

All cohorts excluding discovery

  

23,191

12,991

10,200

  

1.09

1.46E−07

 

All cohorts

  

25,735

14,631

11,104

  

1.13

9.49E−12

 
  1. AA, African–American; EA, European–American; GAIN, The Genetic-Association Information Network; MAF, minor allele frequency; MGS, molecular genetics of schizophrenia; WTCCC, The Wellcome Trust Case–Control Consortium; ZHH, The Zucker Hillside Hospital.
  2. P-values are two-sided for the discovery cohort and combined analyses; one-sided P-values are listed for the replication cohorts.
  3. Cohort details are available in Supplementary Note 1.
  4. *Cohorts not part of Psychiatric Genomics Consortium Phase 1 publications7,10,11.