Figure 3: Strong accumulation of H2a and calnexin in the ERQC in the presence of visible Htt96Q aggregates in striatal neurons. | Nature Communications

Figure 3: Strong accumulation of H2a and calnexin in the ERQC in the presence of visible Htt96Q aggregates in striatal neurons.

From: Soluble forms of polyQ-expanded huntingtin rather than large aggregates cause endoplasmic reticulum stress

Figure 3

(a) The localization of H2a accumulation is not correlated with Htt96Q aggregate localization. Similar to the experiment in Fig. 1c. (b,c) Non-striatal cells are less affected by large Htt96Q aggregates. Similar to the experiments in Fig. 1c,d, but with NIH 3T3 and N2a cells. (d) As in a, but with BiP-GFP expression and Htt96Q-Cherry. Htt96Q aggregation does not affect the disperse pattern of BiP-GFP through the ER. Scale bar, 10 μm in all panels.

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