Figure 6: 17-AAG reduced the number of pathological TDP-43 aggregates.
From: Heat-shock protein dysregulation is associated with functional and pathological TDP-43 aggregation
(a) 17-AAG reduced the number of pathological aggregates that contained TDP-43 C-terminal fragments. The GFP-TDP-43-IIPLD structure that mimics the pathological degraded fragment is illustrated at the top. (b) The number of cells that contained small (<5 μm diameter) or large (>5 μm diameter) TDP-43 aggregates is presented. Scale bars: 10 μm. All the data are presented as the mean±s.d. (n=3). (c) Western blotting was utilized to illustrate the effects of 17-AAG on GFP-TDP-43-IIPLD solubility. (d) The relative intensity of GFP-TDP-43-IIPLD expression in c was analysed. Full-sized immunoblots are included in Supplementary Fig. S8.
