Table 2 Summary association results for rs35252396 and RCC.

From: A common variant at 8q24.21 is associated with renal cell cancer

Study population

Cases ( n)

Controls ( n)

Frequency

OR (95% CI)

P -value

   

Cases

Controls

  

Iceland

1,505

67,725

0.56

0.50

1.30 (1.18, 1.44)

1.8 × 10−7

Spain

130

1,406

0.52

0.45

1.34 (1.03, 1.74)

0.027

The Netherlands

776

2,366

0.49

0.44

1.22 (1.09, 1.37)

6.5 × 10−4

All excl. Iceland

906

3,772

—

0.45

1.24 (1.12, 1.38)

5.9 × 10−5

All combined

2,411

71,497

—

0.46

1.27 (1.18, 1.37)

5.4 × 10−11

Phet=0.67

I2=0%

     
  1. CI, confidence interval; OR, odds ratio; RCC, renal cell carcinoma; SNP, single-nucleotide polymorphism.
  2. Logistic regression was used to test for association between rs35252396[CG] and phenotype. All P-values shown are two-sided. Shown are the corresponding numbers of cases and controls (n), allelic frequencies of variants in affected and control individuals, the allelic OR with 95% CI and P-value. Also shown are the P-values for the heterogeneity of the ORs (Phet) for all study groups, and I2, which lies between 0 and 100%, and describes the proportion of total variation in study estimates that is due to heterogeneity. For the combined study populations, the reported control frequency was the average, unweighted control frequency of the individual populations, whereas the OR and the P-value were estimated using the Mantel–Haenszel model. The Icelandic association results are based on imputed data for both cases and controls. The imputation of data for the Icelandic cases is done using 575 Icelandic patients who had been genotyped using one of the commercial Illumina SNP chips and 930 patients who had at least partial data based on family-based imputation. The imputation of data for the Icelandic controls was done using 25,875 Icelanders who were imputed based on chip genotypes and 41,850 Icelanders who were family-based imputed. The Spanish and Dutch case–control samples were directly genotyped using single-track assay genotyping platform.
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