Figure 6: Schematic representation showing the opposing roles played by miR-1 and miR-206 in the regulation of SARS and VegfAa. | Nature Communications

Figure 6: Schematic representation showing the opposing roles played by miR-1 and miR-206 in the regulation of SARS and VegfAa.

From: miR-1 and miR-206 target different genes to have opposing roles during angiogenesis in zebrafish embryos

Figure 6

In somitic cells, miR-1 serves as a pro-angiogenic modulator by inducing VegfAa expression through repressing SARS expression, whereas miR-206 serves as an anti-angiogenic modulator by directly repressing vegfaa expression. These two pathways control the secreted levels of VegfAa from the somites to regulate angiogenesis.

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