Figure 4: Correlates of protective efficacy.
From: Protective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation
(a) Correlation of time to parasitaemia with ex vivo ELISPOT responses for Ad-MVA vaccinees, P=0.97. (b) Correlation of time to parasitaemia with frequency of CD8+ IFNγ+/IL-2− /TNFα− for Ad-MVA vaccinees, P=0.0005. For vaccinees receiving Ad alone or Ad-MVA (n=24), correlation of time to parasitaemia with frequency of CD8+ IFNγ+/IL-2− /TNFα−, rs=0.61, P=0.002. Both (a) and (b) were assessed at the time of sporozoite challenge. (c) Correlation of time to parasitaemia with frequency of CD107a+/ IFNγ−/IL-2−/TNFα− CD8+ T cells at day 150 post challenge in challenge A, P=0.02. (d) Correlation of parasite density in second replication cycle with frequency CD8+ IFNγ+/IL-2− /TNFα− for Ad-MVA vaccinees. All correlations were performed using two-tailed Spearman’s correlation.
