Figure 2: TRAF1 neuron-specific transgenic mice have enlarged brain lesions after stroke. | Nature Communications

Figure 2: TRAF1 neuron-specific transgenic mice have enlarged brain lesions after stroke.

From: TRAF1 is a critical regulator of cerebral ischaemia–reperfusion injury and neuronal death

Figure 2

(a) Time course of MCAO and reperfusion before sacrifice. (b) Brains of NTG, TG2-TRAF1 and TG4-TRAF1 mice stained with TTC at the indicated times after I/R. Scale bar, 10 mm. (c–e) Quantification of infarct (c), oedema (d) volumes and neurological scores (e) at the indicated times (n=7 at each time point, *P<0.05 versus NTG). (f) Representative images of apoptosis in cortical neurons co-stained with NeuN and TUNEL after 24 h of reperfusion (left). Scale bar, 100 μm. Insets show a higher magnification view. Scale bar, 20 μm. The right panel shows the quantification of TUNEL-positive cells (n=4, *P<0.05 versus NTG). The data represent the mean±s.d. Statistical analysis was carried out by unpaired Student’s t-test.

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