Figure 3: TRAF1 deficiency is neuroprotective during stroke.
From: TRAF1 is a critical regulator of cerebral ischaemia–reperfusion injury and neuronal death
(a) Brains stained with TTC at the indicated times after ischaemia/reperfusion (I/R). Scale bar, 10 mm. (b–d) Quantification of infarct (b) and oedema (c) volumes and neurological scores (d) at the indicated times (n=7 or 12 at each time point, *P<0.05 versus WT). (e) Representative images of apoptosis in cortical neurons of WT and TRAF1-KO mice co-stained with NeuN and TUNEL after 24 h of I/R (left). Scale bar, 100 μm. The inset shows a higher magnification view. Scale bar, 20 μm. The right panel shows quantification of TUNEL-positive cells (n=4, *P<0.05 versus NTG). The data represent the mean±s.d. Statistical analysis was carried out by unpaired Student’s t-test.
