Figure 8: Proposed mechanism of TRAF1-mediated I/R cerebral injury.
From: TRAF1 is a critical regulator of cerebral ischaemia–reperfusion injury and neuronal death
With ischaemia/reperfusion, upregulated TRAF1 facilitates ASK1 phosphorylation at Thr845 through a direct interaction. Activated ASK1 synergistically phosphorylates and activates the MKK/JNK pro-death pathway and inhibits the Akt pro-survival signalling pathway, leading to enhanced neuronal death and cerebral damage.
