Figure 3: Oseltamivir does not suppress H7N9 virus replication in mice infected with rSH/1. | Nature Communications

Figure 3: Oseltamivir does not suppress H7N9 virus replication in mice infected with rSH/1.

From: Influenza A(H7N9) virus gains neuraminidase inhibitor resistance without loss of in vivo virulence or transmissibility

Figure 3

Female BALB/c mice (6–8-week-old; n=5) were infected intranasally with 100 PFU of rSH/1 (blue) or rSH/1:AH/1-NA (purple) viruses. Mice were treated with intranasal zanamivir (a), oral oseltamivir (b), intranasal PBS vehicle (a) or oral distilled water vehicle (b) twice daily for 5 days. Five mice were euthanized at day 5 post infection and viral lung titres were determined by plaque assays in MDCK cells. Student’s t-test was applied to evaluate the statistical significance between viral titres of control animals and antiviral-treated animals. Error bars indicate s.d. value.

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