Figure 5: Wnt7a-CT stimulates the expansion of the satellite stem cell pool.
From: A truncated Wnt7a retains full biological activity in skeletal muscle
(a) Representative images of immunostained sections of TA muscles stained for Pax7 (in red); nuclei are counterstained with Dapi (in blue). Scale bar: 100 μm. (b) Electroporation of a Wnt7a-CT plasmid stimulates the expansion of satellite cells in TA muscles, n=4, *P<0.05. (c) Injection of Wnt7a-CT protein stimulates the expansion of satellite cells in TA muscles, n=4, **P<0.01. (d) Application of Wnt7a-CT stimulates the expansion of the satellite stem cell pool on single fibres after 42 h of culture, n=4, **P<0.01. All P-values were calculated using a two-tailed Student’s t-test. All data are expressed as mean±s.e.m.
