Table 2 Distribution of lipid traits by R19X genotype.

From: A rare functional cardioprotective APOC3 variant has risen in frequency in distinct population isolates

Trait

CC*

CT*

Effect size †

P -value ‡

N

1,219

48

—

—

Sex (M:F)

518:699

23:24

0.943 (0.813, 1.093)

0.435

Age (years)§

62.058 (19.51)

66.234 (17.20)

5.257 (2.944)

0.189

HDL (mmol l−1)

1.265 (0.35)

1.619 (0.30)

0.319 (0.054)

4.65 × 10−9

LDL (mmol l−1)

3.272 (0.94)

3.205 (0.73)

−0.042 (0.143)

0.767

Total cholesterol (mmol l−1)

5.288 (1.10)

5.225 (0.79)

−0.047 (0.167)

0.778

Triglycerides (mmol l−1)

0.313 (0.49)

−0.220 (0.33)

−0.513 (0.075)

1.10 × 10−11

High HDL

232/1209 (0.192%)

28/47 (0.596%)

1.471 (1.305,1.659)

4.29 × 10−10

Low HDL

307/1209 (0.254%)

1/47 (0.021%)

0.812 (0.713,0.924)

1.64 × 10−3

  1. *Untransformed variables are presented as mean (s.d.) and natural logarithm-transformed variables are presented as median (s.d.).
  2. †For continuous traits beta values (standard error) are reported, whereas for binary traits odds ratios and 95% confidence intervals are reported.
  3. ‡P-values are calculated using the likelihood ratio test, as calculated by the GEMMA software.
  4. §Inverse-normalized for analysis.
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