Figure 1: GRAF3 is expressed in a smooth muscle-restricted fashion.
From: The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension
Tissues from Wt mice (2–14-week-old) or human (2 years) were frozen in OCT, sectioned and stained with a specific GRAF3 antibody (red; also see Supplementary Fig. S1 and Supplementary Fig. S2d,e). Some samples were co-stained with PECAM antibody (green). DAPI is shown in blue. a, arteriole/artery; b, bronchi; v, vein; adv., adventitia; Epi., epithelial layer; Mus., smooth muscle layer. Note strong expression of GRAF3 throughout the media of human carotid artery and in the microvessels within the adventitia. Scale bars, 100 microns for mouse tissue and 550 microns for human tissues.
