Figure 3: Structural changes in MloK1 upon cAMP binding.
From: Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1
3D atomistic models are fitted to the maps of the cAMP-bound (mesh, blue) and cAMP-free (solid, yellow) MloK1 structures. (a) Side view of the CNBD region. Upon ligand binding, CNBDs interacts with the N-terminal region of its own monomer’s S1 helix and the S3 helix of its neighbour. (b) The VSD rearrangement viewed from the side. Helices are shown as cylinders. (c) Cross-section through the transmembrane pore and CNBD regions. (d) Extracellular view on inner helices S5 and S6, which twist slightly counter-clockwise on ligand binding.
