Figure 6: EED Knockdown abolishes RING1B occupancy on target genes.
From: The central role of EED in the orchestration of polycomb group complexes
(a) EED is crucial for RING1B binding to PcG target promoters. Genome-wide occupancies of RING1B in Eed+/+ mESCs (red) and Eed−/− mESCs (blue) are noted at all annotated gene promoters. Data from Tavares et al.35 was utilized. (b) Heatmap representation of genomic regions with binding profiles of RING1B in Eed+/+ and Eed−/− mESCs at genes 5 kb flanking TSSs. (c) Differential RING1B binding between Eed+/+ mESCs and Eed−/− mESCs samples in various target genomic regions are shown.
