Figure 7: The proposed model depicting a role for EED in orchestrating PRC2 and PRC1 function in epigenetic regulation.
From: The central role of EED in the orchestration of polycomb group complexes
EED is critical for PRC2 to methylate histone H3 at lysine 27. Once H3K27 are methylated, EED directly recruits PRC1 to the tri-methylated H3K27 loci and enhances PRC1 ubiquitin E3 ligase activity.
