Figure 1: Transcriptional regulation of metabolic pathways in human tumours. | Nature Communications

Figure 1: Transcriptional regulation of metabolic pathways in human tumours.

From: Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer

Figure 1

(a) Differential expression (Z-score) distributions for 51 tumour-versus-normal data sets representing 19 tumour types are shown as violin plots (grey). Dots indicate Z-scores for MTHFD2 in each study; red colour denotes significance at <5% FDR. (b) Distribution of meta-analysis scores for all 20,103 genes interrogated across the 51 data sets. Gene symbols indicated, see text for further description. (c) Metabolic pathways detected as strongly overexpressed (among top 50 metabolic enzymes; red gene symbols) or underexpressed (among bottom 50 metabolic enzymes; blue gene symbols) in tumours. (d) Schematic of one-carbon metabolism with overexpressed (red) and underexpressed (blue) genes indicated. Grey symbols, not measured. (e) Gene set enrichment analysis for the set of 35 embryonic metabolic enzymes compared with mRNAs for all enzymes.

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