Table 2 Top 50 metabolic enzymes frequently underexpressed in human tumours.
Score | Symbol | Description |
|---|---|---|
−24 | ASPA | Aspartoacylase |
−23 | AOX1 | Aldehyde oxidase 1 |
−22 | GPX3 | Glutathione peroxidase 3 (plasma) |
−21 | ADH1B | Alcohol dehydrogenase 1B (class I), beta polypeptide |
−20 | PTGDS | Prostaglandin D2 synthase 21 kDa (brain) |
−20 | MAOB | Monoamine oxidase B |
−20 | AMT | Aminomethyltransferase |
−19 | COX7A1 | Cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) |
−17 | UST | Uronyl-2-sulfotransferase |
−17 | SOD3 | Superoxide dismutase 3, extracellular |
−17 | PTGIS | Prostaglandin I2 (prostacyclin) synthase |
−17 | ADH1C | Alcohol dehydrogenase 1C (class I), gamma polypeptide |
−16 | PIP5K1B | Phosphatidylinositol-4-phosphate 5-kinase, type I, beta |
−16 | PDE2A | Phosphodiesterase 2A, cGMP-stimulated |
−16 | CYP3A5 | Cytochrome P450, family 3, subfamily A, polypeptide 5 |
−16 | ALDH2 | Aldehyde dehydrogenase 2 family (mitochondrial) |
−16 | ALDH1A1 | Aldehyde dehydrogenase 1 family, member A1 |
−15 | ECHDC2 | Enoyl CoA hydratase domain containing two |
−15 | DUOX1 | Dual oxidase 1 |
−15 | ST6GALNAC2 | ST6 -N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 |
−15 | PPAP2B | Phosphatidic acid phosphatase type 2B |
−15 | PLCL1 | Phospholipase C-like 1 |
−15 | IDI1 | Isopentenyl-diphosphate delta isomerase 1 |
−15 | ALDH9A1 | Aldehyde dehydrogenase 9 family, member A1 |
−15 | ACACB | Acetyl-CoA carboxylase beta |
−14 | MAN1C1 | Mannosidase, alpha, class 1C, member 1 |
−14 | CHST3 | Carbohydrate (chondroitin 6) sulfotransferase 3 |
−14 | MAOA | Monoamine oxidase A |
−14 | CYP11A1 | Cytochrome P450, family 11, subfamily A, polypeptide 1 |
−14 | ATP1A2 | ATPase, Na+/K+ transporting, alpha 2 polypeptide |
−14 | ALDH3A2 | Aldehyde dehydrogenase 3 family, member A2 |
−14 | ADH1A | Alcohol dehydrogenase 1A (class I), alpha polypeptide |
−13 | NMRK1 | Nicotinamide riboside kinase 1 |
−13 | INPP5A | Inositol polyphosphate-5-phosphatase, 40 kDa |
−13 | HSD11B1 | Hydroxysteroid (11-beta) dehydrogenase 1 |
−13 | CYP27A1 | Cytochrome P450, family 27, subfamily A, polypeptide 1 |
−13 | CHKB | Choline kinase beta |
−13 | CAT | Catalase |
−12 | ACOX2 | Acyl-CoA oxidase 2, branched chain |
−12 | SRD5A2 | Steroid-5-alpha-reductase, alpha polypeptide 2 |
−12 | SLC6A4 | Solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 |
−12 | PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 (alpha) |
−12 | HMGCS2 | 3-Hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) |
−12 | GSTM1 | Glutathione S-transferase mu 1 |
−12 | GATM | Glycine amidinotransferase (L-arginine:glycine amidinotransferase) |
−12 | ETFDH | Electron-transferring-flavoprotein dehydrogenase |
−12 | CDO1 | Cysteine dioxygenase, type I |
−12 | ATP6V1E1 | ATPase, H+ transporting, lysosomal 31 kDa, V1 subunit E1 |
−12 | ATP1B2 | ATPase, Na+/K+ transporting, beta 2 polypeptide |
−12 | SLC25A4 | Solute carrier family 25 (mitochondrial carrier; ANT), member 4 |
