Table 1 Mitotic arrest EC50 and growth inhibition IC50 values in U2OS cells for hit compounds.
From: Diversity-oriented synthesis as a tool for identifying new modulators of mitosis
Compound code | Mitotic index (MI) EC 50 (μM) | Growth inhibition (GI) 50 (μM) |
---|---|---|
36 | N/A | N/A |
37 | 8.90±0.42 | 4.30±1.13 |
38 | 6.25±0.91 | 3.70±0.71 |
40 | 9.48±1.10 | 4.20±0.62 |
Dosabulin, 41 | 3.13±0.32 | 1.47±0.03 |
(R)-dosabulin | N/A | N/A |
(S)-dosabulin | 1.23±0.10 | 0.81±0.37 |