Table 1 Mitotic arrest EC50 and growth inhibition IC50 values in U2OS cells for hit compounds.

From: Diversity-oriented synthesis as a tool for identifying new modulators of mitosis

Compound code

Mitotic index (MI) EC 50 (μM)

Growth inhibition (GI) 50 (μM)

36

N/A

N/A

37

8.90±0.42

4.30±1.13

38

6.25±0.91

3.70±0.71

40

9.48±1.10

4.20±0.62

Dosabulin, 41

3.13±0.32

1.47±0.03

(R)-dosabulin

N/A

N/A

(S)-dosabulin

1.23±0.10

0.81±0.37

  1. N/A, not active.
  2. Data displayed as mean±s.d., n=3.