Figure 1: Lsd1−/− embryos and trophoblast-specific deletion of Lsd1 exhibit pronounced trophectoderm defects. | Nature Communications

Figure 1: Lsd1−/− embryos and trophoblast-specific deletion of Lsd1 exhibit pronounced trophectoderm defects.

From: Lysine-specific demethylase 1 regulates differentiation onset and migration of trophoblast stem cells

Figure 1

(a) Representative morphology of whole-mount wild-type (WT), constitutively deleted (Lsd1−/−), epiblast-specific (Lsd1Sox2-Cre) and trophoblast-specific Lsd1-deficient (Lsd1Eomes-Cre) embryos at E7.5. (b) Comparison of histological sections of WT, Lsd1−/−, Lsd1Sox2-Cre and Lsd1Eomes-Cre E6.5 embryos by HE staining, immunofluorescence with indicated antibodies and the corresponding IgG controls. Dashed lines circle the Lsd1-deficient parts of the embryos. Arrows indicate ectopic, Eomes-positive cells outside of the region of the extraembryonic ectoderm. The cartoon is depicting the different cell lineages of the E6.5 embryo. Scale bars represent 200 μm (a) and 100 μm (b).

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