Figure 3: USP11-mediated PML stabilization inhibits glioma cell migration and invasion.
From: USP11 regulates PML stability to control Notch-induced malignancy in brain tumours
(a) Western blot analysis of USP11 and PML expression in U251 cells transduced with lentivirus carrying control (−) or PML shRNA and/or USP11 expression construct. (b) Proliferation, migration and invasion capabilities of U251 cells as in a. (c) Western blot analysis of USP11 and PML expression in H4 cells transduced with lentivirus carrying control (−) or indicated shRNAs and/or resistant USP11 (USP11r) construct. (d) H4 cells as in c were transduced with or without lentivirus carrying PML-IV and assayed for proliferation, migration and invasion. Data in panels b and d are mean±s.d. (***P<0.001 by t-test) of three independent experiments.
