Table 1 Validated genes found to regulate trace elements in HeLa cells.
From: Genome-wide RNAi ionomics screen reveals new genes and regulation of human trace element metabolism
Gene | Description | z -score (standard score) | Effect of knockdown |
|---|---|---|---|
DNAJC5 | DnaJ (Hsp40) homologue, subfamily C, member 5 | 3.54 | Increased copper |
DNAJC17 | DnaJ (Hsp40) homologue, subfamily C, member 17 | 5.12 | Increased copper |
IBTK | Inhibitor of Bruton agammaglobulinemia tyrosine kinase | 6.74 | Increased copper |
ATP7A | ATPase, Cu++ transporting, alpha polypeptide (Menkes’ syndrome) | 9.49 | Increased copper* |
SLC6A4 | Neurotransmitter transporter, serotonin, member 4 | 3.53 | Increased copper |
ANKRD9 | Ankyrin repeat domain 9 | 7.18 | Increased copper |
CAMK2N2 | Calcium/calmodulin-dependent protein kinase II inhibitor 2 | 6.02 | Increased copper |
ABCC3 | ATP-binding cassette, subfamily C (CFTR/MRP) | 5.60 | High copper |
RPL14 | Ribosomal protein L14 | 6.56 | Increased selenium |
KCNA1 | Potassium voltage-gated channel, shaker-related subfamily, member 1 | 3.43 | Decreased selenium |
SBP2 | SECIS-binding protein 2 | 6.43 | Decreased selenium* |
TP53I3 | Tumour protein p53 inducible protein 3 | 10.80 | Increased manganese |
TFRC | Transferrin receptor (p90) | 7.14 | Decreased iron* |
